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Divergent One‐Pot Two‐Step Synthesis of Phosphoryl‐Substituted 4‐Quinolones and 3‐Indolinonesстатья
- Авторы: Nuzhdin Ivan, Murashkina Arina, Bezzubov Stanislav, Mitrofanov Alexander, Beletskaya Irina
- Журнал: European Journal of Organic Chemistry
- Год издания: 2025
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Номер статьи: e202401423
- DOI: 10.1002/ejoc.202401423
- Аннотация: In this study, we have developed an approach for the selective two-step synthesis of phosphoryl-substituted 4-quinolones and phosphoryl-substituted 3-indolinones. This was achieved through the reaction of (3-(2-iodoaryl)-3-oxoprop-1-yn-1-yl)phosphonates with anilines followed by Cu-catalyzed intramolecular cyclization of the intermediately formed regioisomeric enamines, which are selectively formed under neat conditions or in the presence of a gold complex as a catalyst. This method allows for the synthesis of a series of phosphoryl-substituted 4-quinolones and phosphoryl-substituted 3-indolinones in good yields.
- Добавил в систему: Митрофанов Александр Юрьевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Eur_J_Org_Chem_-_2025_-_Nuzhdin.pdf | 956,3 КБ | 11 апреля 2025 [MitrofanovAU] |