New tricyclic cage compound as allosteric modulator of the glutamatergic system: synthesis and biological activity

Авторы: Golubeva E.A., Lavrov M.I., Veremeeva P.N., Matthews J., Radchenko E.V., Zamoyski V.L., Grigoriev V.V., Palyulin V.A.
Журнал: Mendeleev Communications
Том: 35
Номер: 2
Год издания: 2025
Издательство: Russian Academy of Sciences
Местоположение издательства: Russian Federation
Первая страница: 142
Последняя страница: 144
DOI: 10.71267/mencom.7654
Аннотация: A new tricyclic derivative of 1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonane was synthesized in three steps using 2-aminoindane-5-carbonitrile. A positive modulatory activity of this compound towards the glutamatergic system in a wide range of nanomolar and subnanomolar concentrations has been demonstrated in electrophysiological studies in vitro using patch clamp technique. A putative binding mode of this compound has been revealed by means of molecular docking and molecular dynamics simulations.
Добавил в систему: Радченко Евгений Валерьевич

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