Аннотация:A method of recording slow ROSP's changes of the brain in chronic animals was used. It has been shown that wakefulness was accompanied by quasisinusoidal oscillations of ROSP (periods-several seconds). During slow sleep, oscillations of ROSP became more complicated and their periods were longer. It is suggested that transitions from sleep to wakefulness and vice versa are connected with removal of maximum of oxidative metabolism tension between bicohemical systems characterized by different rhythms of selfregulation. Rhythmic oscillations of ROSP reveal the possibility of separate functional system of the ROSP of the brain cortex to synchronize their oscillations in the brain tissue (biochemical synergetics).