Carbon Monoxide and Prokaryotic Energy Metabolism

Borisov, V.B.; Forte, E.

Авторы: Borisov Vitaliy B., Forte E.
Журнал: International Journal of Molecular Sciences
Том: 26
Номер: 6
Год издания: 2025
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 2809
DOI: 10.3390/ijms26062809
Аннотация: Carbon monoxide (CO) plays a multifaceted role in both physiology and pathophysiology. At high levels, it is lethal to humans due to its tight binding to globins and cytochrome c oxidase. At low doses, CO can exhibit beneficial effects; it serves as an endogenous signaling molecule and possesses antibacterial properties, which opens up possibilities for its use as an antimicrobial agent. For this purpose, research is in progress to develop metal-based CO-releasing molecules, metal-free organic CO prodrugs, and CO-generating hydrogel microspheres. The energy metabolism of prokaryotes is a key point that may be targeted by CO to kill invading pathogens. The cornerstone of prokaryotic energy metabolism is a series of membrane-bound enzyme complexes, which constitute a respiratory chain. Terminal oxidases, at the end of this chain, contain hemes and are therefore potential targets for CO. However, this research area is at its very early stage. The impact of CO on bacterial energy metabolism may also provide a basis for biotechnological applications in which this gas is present. This review discusses the molecular basis of the effects of CO on microbial growth and aerobic respiration supported by different terminal oxidases in light of recent findings.
Добавил в систему: Борисов Виталий Борисович

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№	Имя	Описание	Имя файла	Размер	Добавлен
1.	Экспертное заключение		Borisov.pdf	54,6 КБ	22 мая 2025 [antohina]
2.	Полный текст		ijms-26-02809.pdf	3,4 МБ	22 марта 2025 [vibor]

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