Tetracationic tetraaryltetranaphtho[2,3]porphyrins for photodynamic inactivation against Staphylococcus aureus biofilm

Mi, L.; Xu, T.; Peng, Y.; Strakhovskaya, M.G.; Zhang, Y.; Meerovich, G.A.; Nyokong, T.; Yan, Y.; Chen, Z.

Авторы: Mi Le, Xu Tao, Peng Ying-Yuan, Strakhovskaya Marina G., Zhang Yi-Jing, Meerovich Gennady A., Nyokong Tebello, Yan Yi-Jia, Chen Zhi-Long
Журнал: European Journal of Medicinal Chemistry
Том: 290
Номер: June
Год издания: 2025
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 117558
DOI: 10.1016/j.ejmech.2025.117558
Аннотация: Antimicrobial photodynamic therapy (aPDT) has emerged as a promising strategy for addressing bacterial infections, particularly those involving biofilm formation. The electrostatic attraction between the negatively charged bacterial cell walls and the cationic charges of photosensitizers facilitates the accumulation of PSs on bacterial surfaces, thereby enhancing aPDT efficacy. In this study, three series of tetracationic tetraaryltetranaphtho[2,3]porphyrins (TNPs), each incorporating different cationic groups with alkyl chains of varying lengths, were designed and synthesized. Their photodynamic inactivation efficacy against S. aureus, E. coli and C. albicans was evaluated, respectively. These TNPs exhibited strong absorption at ∼730 nm with high molar extinction coefficients (>51,500 L·mol−1·cm−1), fluorescence emission at ∼758 nm and efficient singlet oxygen generation capabilities. Among them, TNPs with shorter alkyl chains (I1, II1 and Ⅲ1) exhibited enhanced phototoxicity against planktonic microbes, with I1 (containing pyridinium substituents) showing the highest activity. These three compounds effectively disrupted mature S. aureus biofilms, with Ⅲ1 (bearing diethylmethylammonium groups) demonstrating superior biofilm eradication capabilities. These findings highlight the dual antibacterial and biofilm-disrupting potential of these Ar4TNP derivatives. Furthermore, their selective toxicity toward bacterial cells over mammalian cells at therapeutic doses provides a foundation for developing safer antimicrobial agents, offering promising alternatives to antibiotics for tackling drug-resistant pathogens and persistent biofilm-associated infections.
Добавил в систему: Страховская Марина Глебовна

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Tetracationic tetraaryltetranaphtho[2,3]porphyrins for photodynamic inactivation against Staphylococcus aureus biofilmстатья

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