Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model

Boudenot, A.; Presle, N.; Uzbekov, R.; Toumi, H.; Pallu, S.; Lespessailles, E.

Авторы: Boudenot A., Presle N., Uzbekov R., Toumi H., Pallu S., Lespessailles E.
Журнал: Osteoarthritis and Cartilage
Том: 22
Номер: 8
Год издания: 2014
Издательство: W. B. Saunders Co., Ltd.
Местоположение издательства: United Kingdom
Первая страница: 1176
Последняя страница: 1185
DOI: 10.1016/j.joca.2014.05.020
Аннотация: The role of subchondral bone in osteoarthritis (OA) development is well admitted. Cross-talk between subchondral bone and cartilage may be disrupted in OA, leading to altered subchondral bone remodeling. Osteocytes are involved in bone remodeling control and could play a key role in OA progression. Our purpose of this study was to evaluate the preventive effect of interval-training exercise on subchondral bone and osteocyte in monosodium iodoacetate (MIA) model of experimental OA.\ At baseline, 48 male Wistar rats (8 weeks old) were separated into two groups: interval-training exercise or no exercise for 10 weeks. After this training period, each group was divided into two subgroups: MIA-injected knee (1 mg/100 Î¼l saline) and saline-injected knee. Four weeks later, rats were sacrificed and carefully dissected. Evaluated parameters were: cartilage degeneration by OA scoring, bone mineral density (BMD) by Dual energy X-ray Absorptiometry (DXA), trabecular subchondral bone microarchitecture by micro-computed tomography (Î¼CT), cortical subchondral bone lacunar osteocyte occupancy (by Toluidine Blue staining) and cleaved caspase-3 positive apoptosis (by epifluorescence).\ Our results showed deleterious effects of MIA on cartilage. OA induced a decrease in proximal tibia (PT) BMD which was prevented by exercise. Exercise induced increase in full osteocyte lacunae surface and osteocyte occupancy (+60%) of cortical subchondral bone independently of OA. Osteocyte apoptosis (<1%) in cortical subchondral bone was not different whatever the group at sacrifice.\ Our results suggest that preliminary interval-training improved BMD and osteocytes lacunar occupancy in subchondral bone. Our interval-training did not prevent MIA-induced cartilage degeneration.
Добавил в систему: Узбеков Рустем Эдуардович

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Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis modelстатья

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