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Protective action of glutamate antibodies on increased expression of genes of programmed death of rat brain cells inducted by injection of a β-amyloid fragment (25–35)статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 апреля 2025 г.
- Авторы: Kolobov V.V., Davydova T.V., Fomina V.G.
- Журнал: Biology Bulletin
- Том: 41
- Номер: 2
- Год издания: 2014
- Издательство: M A I K Nauka - Interperiodica
- Местоположение издательства: Russian Federation
- Первая страница: 118
- Последняя страница: 125
- Номер статьи: 3
- DOI: 10.1134/S1062359014020034
- Аннотация: Glutamate antibodies intranasally administered to Wistar rats at a dose of 300 μg/kg reduced the elevated levels of expression of Aifm1, Casp3, and Parp1 genes in the prefrontal cortex and Aifm1 and Casp3 genes in the hippocampus on the third day after administration of the β-amyloid fragment Aβ25-35 into the Meynert nuclei of the brain. Changes in Aifm1, Bax, Casp3, and Parp1 gene expression were not found in the hypothalamus, and changes in Bax gene expression were not found in the brain structures studied. The discovered features of gene expression in the prefrontal cortex and hippocampus are considered in terms of development of various cell-death programs, which are modulated by glutamate antibodies. © 2014 Pleiades Publishing, Inc.
- Добавил в систему: Колобов Виталий Викторович