Genetic Modification of the Association between Peripubertal Dioxin Exposure and Pubertal Onset in a Cohort of Russian Boys

Humblet, O.; Korrick, S.A.; Williams, P.L.; Sergeyev, O.; Emond, C.; Birnbaum, L.S.; Burns, J.S.; Altshul, L.M.; Patterson, D.G.; Jr; Turner, W.E.; Lee, M.M.; Revich, B.; Hauser, R.

Авторы: Humblet Olivier, Korrick Susan A., Williams Paige L., Sergeyev Oleg, Emond Claude, Birnbaum Linda S., Burns Jane S., Altshul Larisa M., Patterson Donald G., Jr, Turner Wayman E., Lee Mary M., Revich Boris, Hauser Russ
Журнал: Environmental Health Perspectives
Том: 121
Номер: 1
Год издания: 2013
Издательство: US Department of Health and Human Services
Местоположение издательства: United States
Первая страница: 111
Последняя страница: 117
DOI: 10.1289/ehp.1205278
Аннотация: BACKGROUND: Exposure to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies. Whether genetic polymorphisms may modify this association is currently unknown. Identifying such genes could provide insight into mechanistic pathways. This is one of the first studies to assess genetic susceptibility to dioxins. OBJECTIVES: We evaluated whether common polymorphisms in genes affecting either molecular responses to dioxin exposure or pubertal onset influence the association between peripubertal serum dioxin concentration and male pubertal onset. METHODS: In this prospective cohort of Russian adolescent boys (n = 392), we assessed gene-environment interactions for 337 tagging single-nucleotide polymorphisms (SNPs) from 46 candidate genes and two intergenic regions. Dioxins were measured in the boys' serum at age 8-9 years. Pubertal onset was based on testicular volume and on genitalia staging. Statistical approaches for controlling for multiple testing were used, both with and without prescreening for marginal genetic associations. RESULTS: After accounting for multiple testing, two tag SNPs in the glucocorticoid receptor (GR/NR3C1) gene and one in the estrogen receptor-alpha (ESR1) gene were significant (q < 0.2) modifiers of the association between peripubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although not by testicular volume. The results were sensitive to whether multiple comparison adjustment was applied to all gene-environment tests or only to those with marginal genetic associations. CONCLUSIONS: Common genetic polymorphisms in the glucocorticoid receptor and estrogen receptor-alpha genes may modify the association between peripubertal serum dioxin concentration and pubertal onset. Further studies are warranted to confirm these findings.
Добавил в систему: Сергеев Олег Владимирович

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Genetic Modification of the Association between Peripubertal Dioxin Exposure and Pubertal Onset in a Cohort of Russian Boysстатья

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