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Bio-Medical Applications of Magnetic Diamond Nanoparticlesтезисы доклада
- Авторы: Karmenyan A., Perevedentseva E., Lin Y.C., Song C.Y., Lin Z.R., Liu L.C., Norina S., Bessalova V., Perov N., Cheng C.L.
- Сборник: Book of Abstracts of Moscow International Symposium on Magnetism (MISM-2017)
- Тезисы
- Год издания: 2017
- Место издания: Москва
- Первая страница: 700
- Последняя страница: 700
- Аннотация: Development of nanoparticles (NP) applications for bio-medical research and theranostic is recently focused on multifunctional NP, with integration of various functionalities. The multifunctional NP are designed to co-deliver multiple components, control the delivery, realizing drug and diagnosis simultaneously. To integrate several functionalities, different methods of surface functionalization and modifying the particles physical properties are developed. Number of NP can reveal wide variability of utilized properties: noble metals NP, carbon- and silicon- based NP of different structure, metal oxides and metal-doped NP, polymer NP, etc., as well as their composites [1]. Among these NP nanodiamond (ND) is promising for development of multifunctional complex due to their widely variable features in sizes, structure, surface chemistry, physical properties and their biocompatibility [2]. Additionally to well-studied structural, surface, electrochemical and photonic properties of ND, strong magnetism can be observed in carbons and nanocarbons. The origin of ferromagnetic and superparamagnetic properties in carbon nanostructures containing intermediate graphite–diamond ordering is studied [3]. In this work we characterise and discuss magnetic-modified ND (Ray Techniques, Israel) [4]. The strong magnetic susceptibility of this ND has been demonstrated. Additionally the ND reveals strong fluorescence at two-photon excitation, and well-detectable signal at fluorescence lifetime analysis. The origins of the magnetism and fluorescence are discussed. The ND has been characterized, first of all, in terms of its bioapplications. The ND biocompatibility and methods of improving biocompatibility are demonstrated. ND interaction with cells and 3D cellular structures [5] with and without applied magnetic field [6] was observed. The combining fluorescence and magnetic properties of ND with its biocompatibility make it promising for various imaging and delivery bio-applications, e.g. to realize and observe magnetic filtration, magnetic-guided delivery, magnetic-assisted 3D cellular growth. Support by the Ministry of Science and Technology of Taiwan, Grant No. MOST 103-2112-M-259-001-MY3 is acknowledged. We also are grateful to Dr. O. Levinson (Ray Techniques) for the provided ND samples. [1] G. Bao et al., Annu. Rev. Biomed. Eng., 15 (2013) 253-282. [2] E. Perevedentseva, et al., Future Medicine. Nanomedicine, 8 (2013) 2041-2060. [3] O. Levinson et al., J. Nanoscience & Nanotechnology, 15 (2015) 1045-1052. [4] T. L. Makarova, Semiconductors, 38 (2004) 615-638. [5] H.-L. Ma et al., Molecular Imaging, 11 (2012) 487-498. [6] W. M. Guo et al., Mol. Pharmaceutics, 11 (2014) 2182-2189.
- Добавил в систему: Норина Светлана Борисовна