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Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressureстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 ноября 2017 г.
- Авторы: Kroetsch JT, Levy AS, Zhang H., Aschar-Sobbi R., Lidington D., Offermanns S., Nedospasov SA, Backx PH, Heximer SP, Bolz SS
- Журнал: Nature communications
- Том: 8
- Год издания: 2017
- Издательство: Nature Pub. Group
- Местоположение издательства: United Kingdom
- Первая страница: 14805
- DOI: 10.1038/ncomms14805
- Аннотация: Tumour necrosis factor (TNF) is a ubiquitously expressed cytokine with functions beyond the immune system. In several diseases, the induction of TNF expression in resistance artery smooth muscle cells enhances microvascular myogenic vasoconstriction and perturbs blood flow. This pathological role prompted our hypothesis that constitutively expressed TNF regulates myogenic signalling and systemic haemodynamics under non-pathological settings. Here we show that acutely deleting the TNF gene in smooth muscle cells or pharmacologically scavenging TNF with etanercept (ETN) reduces blood pressure and resistance artery myogenic responsiveness; the latter effect is conserved across five species, including humans. Changes in transmural pressure are transduced into intracellular signals by membrane-bound TNF (mTNF) that connect to a canonical myogenic signalling pathway. Our data positions mTNF 'reverse signalling' as an integral element of a microvascular mechanosensor; pathologic or therapeutic perturbations of TNF signalling, therefore, necessarily affect microvascular tone and systemic haemodynamics
- Добавил в систему: Взорова Нина Владимировна