Аннотация:Carbocyanine dyes, due to their ability to effectively bind to transport proteins, can be used as biomarkers. In this connection, one of the promising directions in medicinal chemistry is currently a synthetic design based on carbocyanine fluorophores in order to create structures with given photophysical properties. The main requirements for such structures are a high extinction coefficient and a high quantum yield of fluorescence. The absorption and fluorescence interval in such structures is convenient to change due to the variation of the substituents in the structural fragments.
The least studied in this class of compounds are bichromophores based on bispyrrolenine and benzindolenine heterocycles, presented in the literature as separate examples containing only methyl substituents on nitrogen atoms [1, 2].
In the framework of this study, a scheme for the synthesis of bis-dicarbocyanines with benzpyrrolenin scaffold 4 and containing several hydrophilic groups has been developed.
The research was carried out with the financial support of the Grant of the President of the Russian Federation for the state support of the leading scientific schools NSh-10268.2016.3