|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Heterocyclic analogs of 5,12-naphthacenequinone 10.* Synthesis of furanoquinizarine and its new derivativesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 ноября 2017 г.
- Авторы: Tikhomirov A.S., Shchekotikhin A.E., Luzikov Yu N., Korolev A.M., Preobrazhenskaya M.N.
- Журнал: Chemistry of Heterocyclic Compounds
- Том: 47
- Номер: 10
- Год издания: 2012
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 1206
- Последняя страница: 1211
- DOI: 10.1007/s10593-012-0895-4
- Аннотация: A new method was developed for synthesis of anthra[2,3-b]furan-5,10-dione derivatives. The key compound for annelation of the furan fragment to the anthraquinone chromophor is the previously unknown analog of salicylaldehyde, 1,4-dimethoxy-3-formyl-2-hydroxyanthraquinone, which we have synthesized by the Miller–Loudon–Schneider reaction. A chain of sequential transformations was used for its conversion into the target 4,11-dihydroxyanthra[2,3-b]furan-5,10-dione (furanoquinizarine): O-alkylation of the starting formylhydroxyanthraquinone with bromoacetic acid esters, cyclo-dehydration of the 3-formylanthraquinon-2-ylacetic acid esters in the presence of bases, hydrolysis of the obtained esters to 4,11-dimethoxy-5,10-dioxo-5,10-dihydroanthra[2,3-b]furan-2-carboxylic acid, its decarboxylation, and demethylation of the obtained 4,11-dimethoxyanthra[2,3-b]furan-5,10-dione.
- Добавил в систему: Тихомиров Александр Сергеевич