Study of F-actin interaction with planar and liposomal bilayer phospholipid membranesстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 3 февраля 2015 г.
Аннотация:Interaction of the cytoskeletal protein F-actin with planar bilayer lipid membrane (BLM) induced formation of single ionic channels in both NaCl and KCl bathing solutions. We also recorded noiselike high-current jumps with a mean conductivity of similar to 160 pS, which might represent the simultaneous opening and closing of several channels of loner conductivity. The ratio of cation to anion permeabilities (Pc/Pa) of the BLM with many channels in KCI was 26 +/- 2, Freeze fracture electron microscopy revealed fibrillar-like structures on the hydrophobic surfaces of liposomal membranes. We also observed some structural features giving evidence for the penetration of F-actin fibers through an artificial phospholipid membrane. We suggest that the F-actin/lipids complexes can transmit electric signals in synaptic and other intercellular contacts.