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a,a-Difluoro-b-ketophosphonates on a tetraazamacrocyclic platform: Synthesis and inhibitory activity against protein tyrosine phosphatasesстатья
- Авторы: Khavrienko D.I., Kobzar O.L., Shevchuk M.V., Romanenko V.D., Kobelev S.M., Averin A.D., Beletskaya I.P., Vovk A.I., Kukhar V.P.
- Журнал: Доповiдi НАНУ
- Номер: 9
- Год издания: 2014
- Первая страница: 109
- Последняя страница: 115
- Аннотация: The present study offers a new approach for designing inhibitors of protein tyrosine phosphatases. We have synthesized the cyclam derivatives with a,a-difluoro-b-ketophosphonate fragments covalently attached to tetraazamacrocyclic scaffold, which is known to be of medical interest. The obtained functionalized macrocycles were evaluated as inhibitors of PTP1B, TC-PTP, CD45, and other protein tyrosine phosphatases.
- Добавил в систему: Аверин Алексей Дмитриевич