Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specificстатья
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Дата последнего поиска статьи во внешних источниках: 22 апреля 2015 г.
Аннотация:The human gastrointestinal tract is inhabited by a diverse and dense symbiotic microbiota, the
composition of which is the result of host–microbe co-evolution and co-adaptation. This tight
integration creates intense cross-talk and signaling between the host and microbiota at the
cellular and metabolic levels. In many genetic or infectious diseases the balance between host
and microbiota may be compromised resulting in erroneous communication. Consequently, the
composition of the human metabolome, which includes the gut metabolome, may be different
in health and disease states in terms of microbial products and metabolites entering systemic
circulation. To test this hypothesis, we measured the level of hydroxy, branched, cyclopropyl and
unsaturated fatty acids, aldehydes, and phenyl derivatives in blood of patients with a hereditary
autoinflammatory disorder, familial Mediterranean fever (FMF), and in patients with peptic
ulceration (PU) resulting from Helicobacter pylori infection. Discriminant function analysis of
a data matrix consisting of 94 cases as statistical units (37 FMF patients, 14 PU patients, and
43 healthy controls) and the concentration of 35 microbial products in the blood as statistical
variables revealed a high accuracy of the proposed model (all cases were correctly classified).
This suggests that the profile of microbial products and metabolites in the human metabolome
is specific for a given disease and may potentially serve as a biomarker for disease.