Аннотация:Genetic factors definitely contribute to the aetiology and pathogenesis of migraine. A number of others studies have been conducted to better define genetic predisposition to dopamine metabolism disorders. The objective we had in this study was to evaluate the effect of the С and Т alleles of DBH gene polymorphism rs1611115 (c.-979T>C) on the clinical characteristics of migraine. The retrospective study included 132 patients with migraine and control group included 348 unexamined subjects (population control), all living in Moscow and Moscow region. Genotypes were identified by PCR-RFLP method using FauI endonuclease. We demonstrated the role played by polymorphism at the promoter region of the DBH gene (rs1611115, allele T) in the development of the following clinical characteristics of migraine (p<0.05): allodynia, prodrome, postdrome, vomiting, aura, and the number of taken drugs. The data we obtained confirm the involvement of the dopaminergic system in the pathogenesis of migraine, particularly at the attack initiation stage.
