MICROBIAL COMMUNICATION AND  MICROBIOTA-HOST INTERACTIONS: BIOMEDICAL, BIOTECHNOLOGICAL, AND BIOPOLITICAL  IMPLICATIONS

Oleskin, A.V.; Shenderov, B.A.

Авторы: Oleskin A.V., Shenderov B.A.
Год издания: 2020
Издательство: Nova Science Publishers, Inc.
Местоположение издательства: United States
Объём: 256 страниц (22,0 печатных листов)
Тираж: 500 экз.
Монография
DOI: 10.52305/EGCB8622
Аннотация: In light of recent data, microorganisms are construed in the present monograph as living organisms that are capable of communication and advanced social organization, which conspicuously manifests itself in the formation of intercellular matrix-enclosed biofilms. Microbial communication signals, including quorum sensing pheromones, are of paramount importance both for interactions among microbial cells and the dialogue between them and the host organism. The microbiota inhabits various niches of the host organism, especially the gastro-intestinal tract. Microorganisms release diverse signal molecules and, in addition, specifically respond to host signals. This enables them to constantly interact with the nervous system, including the brain, and the immune system of the host organism. This ongoing dialogue may either stabilize the host’s physical and mental health state or, alternatively, cause serious health problems. Interactions in the brain-gut-microbiota axis are normalized and the host’s health is promoted by useful microorganisms (probiotics), including psychobiotics that directly influence human psyche and behavior. Evolutionarily conserved signals used in the communication between microbiota and the host include neuroactive substances (neurochemicals). The influence of symbiotic and opportunistic microorganisms on the host’s physiological, biochemical, immunological, and behavioral activities is mediated by a large number of neurochemicals, such as peptides, amine acids, biogenic amines, short-chain fatty acids, and gaseous substances. The low molecular weight substances function as nutrient substrates, effectors, cofactors, and, most important, signals. Current research on the population organization, social behavior, and intercellular communication of microorganisms is expected to promote the interdisciplinary dialogue between microbiology, cytology, and ethology. In addition, the results of this research are of significant potential importance for medicine and biotechnology.
Добавил в систему: Олескин Александр Владимирович

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