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Mannosylated Polymeric Ligands for Targeted Delivery of Antibacterials and Their Adjuvantsto Macrophages for the Enhancement of the Drug Efficiencyкнига
- Авторы: Zlotnikov Igor D., Ezhov Alexander A., Vigovskiy Maksim A., Grigorieva Olga A., Belogurova Natalya G., Kudryashova Elena
- Год издания: 2024
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Объём: 59 страниц (3,5 печатных листов)
- ISBN: 978-3-7258-0465-8
- Монография
- DOI: 10.3390/books978-3-7258-0465-8
- Аннотация: doi.org/10.3390/books978-3-7258-0465-8Carbohydrates are one of the four major classes of biomolecules. They play important rolesin various biological processes, including inflammation and immune response, angiogenesis andmetastasis of cancer cells, viral and bacterial infections, and many other cell–cell communications.The tremendous efforts made by glycoscientists in recent decades have allowed carbohydrate-baseddrugs to pave the way for an anonymous area of the therapeutic world.Medicinal chemists use carbohydrates, particularly mono- and disaccharides, as valuablecarriers or key substructures in order to improve the pharmaceutical phase, pharmacokinetics, andpharmacodynamics of well-known drugs. Resorting to the prodrug strategy or multitarget drugs,the conjugation of a traditional drug to carbohydrates allows many limitations of the parent drug tobe overcome, such as lack of site of action specificity, toxicity, and chemical instability. Additionally,carbohydrate-based nanosystems have been shown to better deliver the starting drug or generateselective targeting towards specific body districts, as well as improve the cellular permeability andtoxicological profile of the parent drug.In this Special Issue, “Carbohydrate-Based Drugs”, we aim to collect both original articlesand up-to-date reviews that focus on the design, synthesis, and biological evaluations of novelcarbohydrate-based drugs, with a focus on carbohydrate-based prodrugs and nanosystems.
- Добавил в систему: Кудряшова Елена Вадимовна