Bacterial and Eukaryotic Porins: Structure, Function, Mechanism, Chapter 16: Function of the Outer Mitochondrial Membrane Pore (Voltage-Dependent Anion Channel) in Intracellular Signalingкнига
Аннотация:
Keywords:
function of the outer mitochondrial membrane pore in intracellular signaling;
structure and isotypes of VDAC;
influence of phospholipids on VDAC structure;
VDAC conductance and ion selectivity;
porins as specific binding sites;
cytochrome c;
VDAC–ANT complexes
Summary
This chapter contains sections titled:
Introduction
Structure and Isotypes of VDAC
The Influence of Phospholipids on VDAC Structure
VDAC Conductance and Ion Selectivity
Physiological Significance of the Voltage Dependence
Porins as Specific Binding Sites
VDAC senses Inner Membrane Functions in the Contact Site
Cytochrome c is a Component of the Contact Sites
Isolation and Characterization of VDAC–ANT Complexes
Reconstitution of VDAC–ANT Complexes
Importance of Metabolic Channeling in Regulation of Energy Metabolism
The VDAC–ANT Complex as Permeability Transition Pore
The VDAC–ANT Complex as a Target for Bax-dependent Cytochrome c Release
The VDAC–ANT Complexes contain Cytochrome c
The Importance of the Kinases in Regulation of Apoptosis
Suppression of Bax-dependent Cytochrome c and Permeability Transition by Hexokinase
Suppression of Permeability Transition by Mitochondrial Creatine Kinase