Effects of Lithium Ions on tPA-Induced Hemorrhagic Transformation under Stroke

Babenko, V.A.; Yakupova, E.I.; Pevzner, I.B.; Bocharnikov, A.D.; Zorova, L.D.; Fedulova, K.S.; Grebenchikov, O.A.; Kuzovlev, A.N.; Grechko, A.V.; Silachev, D.N.; Rahimi-Moghaddam, P.; Plotnikov, E.Y.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 июля 2024 г.

Авторы: Babenko Valentina A., Yakupova Elmira I., Pevzner Irina B., Bocharnikov Alexey D., Zorova Ljubava D., Fedulova Kseniya S., Grebenchikov Oleg A., Kuzovlev Artem N., Grechko Andrey V., Silachev Denis N., Rahimi-Moghaddam Parvaneh, Plotnikov Egor Y.
Журнал: BIOMEDICINES
Том: 12
Номер: 6
Год издания: 2024
Первая страница: 1325
Последняя страница: 1325
DOI: 10.3390/biomedicines12061325
Аннотация: Thrombolytic therapy with the tissue plasminogen activator (tPA) is a therapeutic optionfor acute ischemic stroke. However, this approach is subject to several limitations, particularly theincreased risk of hemorrhagic transformation (HT). Lithium salts show neuroprotective effects instroke, but their effects on HT mechanisms are still unknown. In our study, we use the models ofphotothrombosis (PT)-induced brain ischemia and oxygen-glucose deprivation (OGD) to investigatethe effect of Li+ on tPA-induced changes in brain and endothelial cell cultures. We found that tPAdid not affect lesion volume or exacerbate neurological deficits but disrupted the blood–brain barrier.We demonstrate that poststroke treatment with Li+ improves neurological status and increasesblood–brain barrier integrity after thrombolytic therapy. Under conditions of OGD, tPA treatmentincreased MMP-2/9 levels in endothelial cells, and preincubation with LiCl abolished this MMPactivation. Moreover, we observed the effect of Li+ on glycolysis in tPA-treated endothelial cells,which we hypothesized to have an effect on MMP expression.
Добавил в систему: Якупова Эльмира Ильдаровна

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Effects of Lithium Ions on tPA-Induced Hemorrhagic Transformation under Strokeстатья

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